SurgeonsinNewYorkhave performed thefirst-ever whole-eyetransplantina human, theyannouncedon Thursday, an accomplishment being hailed as a breakthrough even though the patient has not regained sightintheeye.
Inthe six months since the surgery, performed during a partial facetransplant, the graftedeyehas shown important signs of health, including well-functioning blood vessels and a promising-looking retina, according to the surgical team at NYU Langone Health.
“The mere fact that wetransplantedaneyeis a huge step forward, something that for centuries has been thought about, but it’s never been performed,” said Dr. Eduardo Rodriguez, who led the team.
Until now, doctors have only been able totransplantthe cornea, the clear front layer of theeye.
The recipient of theeye, Aaron James, is a 46-year-old military veteran from Arkansas who survived a work-related high-voltage electrical accident that destroyed the left side of his face, his nose, his mouth and his lefteye.
Thetransplantsurgery took 21 hours.
Initially, doctors were just planning to include the eyeball as part of the facetransplantfor cosmetic reasons, Rodriguez said during a Zoom interview.
“If some form of vision restoration occurred, it would be wonderful, but… the goal was for us to perform the technical operation,” and have the eyeball survive, Rodriquez added.
Whatever happens going forward will be monitored, he said.
Presently, thetransplantedeyeis not communicating with the brain through the optic nerve.
To encourage healing of the connection between the donor and recipient optic nerves,surgeonsharvested adult stem cells from the donor’s bone marrow and injected them into the optic nerve during thetransplant, hoping they would replace damaged cells and protect the nerve.
Transplantationof a viableeyeglobe opens manynewpossibilities, Rodriguez said, even if sight is not restoredinthis case.
Other research teams are developing ways to connect nerve networksinthe brain to sightlesseyesthrough insertion of electrodes, for example, to allow vision, he said.
“If we can work with other scientists that are working on other methods of restoring vision or restoring images to the visual cortex, I think we’re one step closer,” Rodriguez said.
James, who had retained visioninhis righteye, knew he might not regain visioninthetransplantedeye.
The doctors “never expected it to work at all, and they told me that from the get-go,” he said.
“I told them, ‘even if I can’t see… maybe at least you all can learn something to help the next person.’ That’s how you get started,” he said. “Hopefully this opens up anewpath.”
James might still regain sightinthetransplantedeye, Rodriguez said.
“I don’t think anyone can claim that he will see. But by the same token, they can’t claim that he will not see,” Rodriguez said. “At this point, I think we’re pretty happy with the result that we were able to achieve with a very technically demanding operation.”
(Published 09 November 2023, 16:48 IST)